The Journal of Infectious Diseases, jiac192,

Frederic Reicherz, Rui Yang Xu, Bahaa Abu-Raya, Abdelilah Majdoubi, Christina Michalski, Liam Golding, Aleksandra Stojic, Marina Vineta, Madison Granoski, Zenon Cieslak,  Anil Chacko, Neil Desai, Inna Sekirov, David J. Marchant, Pascal M. Lavoie

Health jurisdictions have seen a near-disappearance of Respiratory Syncytial Virus (RSV) during the first year of the COVID-19 pandemic. Over a corresponding period, we report a reduction in RSV antibody levels and neutralization in women and infants one year into the COVID-19 pandemic (February – June 2021) compared to earlier in the pandemic (May – June 2020), in British Columbia (BC), Canada. This supports that humoral immunity against RSV is relatively short-lived and its establishment in infants requires repeated viral exposure. Waned immunity in young children may explain the inter-seasonal resurgence of RSV cases in BC as seen also in other countries.

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